Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 11 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
A4UGR9 A4UGR9 O75923 XIRP2 DYSF human exp
A4UGR9 A4UGR9 O75530 XIRP2 EED human ortho
A4UGR9 A4UGR9 P20929 XIRP2 NEB human exp
A4UGR9 A4UGR9 P35609 XIRP2 ACTN2 human pred
A4UGR9 A4UGR9 Q14315 XIRP2 FLNC human exp
A4UGR9 A4UGR9 O76041 XIRP2 NEBL human exp
A4UGR9 A4UGR9 Q5S007 XIRP2 LRRK2 human exp
A4UGR9 A4UGR9 O60216 XIRP2 RAD21 human exp
A4UGR9 A4UGR9 Q92636 XIRP2 NSMAF human exp
A4UGR9 A4UGR9 Q15327 XIRP2 ANKRD1 human ortho
A4UGR9 A4UGR9 Q9BXW9 XIRP2 FANCD2 human ortho

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.