Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 16 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
O00253 O00253 P28799 AGRP GRN human exp
O00253 O00253 Q9NR28 AGRP DIABLO human pred
O00253 O00253 O75882 AGRP ATRN human pred
O00253 O00253 P01189 AGRP POMC human pred
O00253 O00253 P32245 AGRP MC4R human exp,pred
O00253 O00253 Q04721 AGRP NOTCH2 human exp
O00253 O00253 P23142 AGRP FBLN1 human exp
O00253 O00253 Q9H3F6 AGRP KCTD10 human exp
O00253 O00253 O75056 AGRP SDC3 human pred
O00253 O00253 P41968 AGRP MC3R human exp,pred
O00253 O00253 P04183 AGRP TK1 human exp
O00253 O00253 Q9NR09 AGRP BIRC6 human exp
O00253 O00253 Q5JS37 AGRP NHLRC3 human exp
O00253 O00253 P33032 AGRP MC5R human exp
O00253 O00253 Q9H672 AGRP ASB7 human exp
O00253 O00253 Q9UBU3 AGRP GHRL human exp,pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.