Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 18 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
O14521 O14521 O75208 SDHD COQ9 human exp
O14521 O14521 P40925 SDHD MDH1 human pred
O14521 O14521 O14957 SDHD UQCR11 human pred
O14521 O14521 A1L0T0 SDHD ILVBL human pred
O14521 O14521 P21359 SDHD NF1 human pred
O14521 O14521 P07954 SDHD FH human pred
O14521 O14521 P22695 SDHD UQCRC2 human pred
O14521 O14521 P31040 SDHD SDHA human pred
O14521 O14521 O95336 SDHD PGLS human pred
O14521 O14521 P31930 SDHD UQCRC1 human pred
O14521 O14521 Q99643 SDHD SDHC human pred
O14521 O14521 P55085 SDHD F2RL1 human exp
O14521 O14521 Q9HC97 SDHD GPR35 human exp
O14521 O14521 P49286 SDHD MTNR1B human exp
O14521 O14521 P05141 SDHD SLC25A5 human exp
O14521 O14521 P07949 SDHD RET human pred
O14521 O14521 P08574 SDHD CYC1 human pred
O14521 O14521 Q9UHL4 SDHD DPP7 human pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.