Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 27 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
O15054 O15054 P84022 KDM6B SMAD3 human exp
O15054 O15054 P67870 KDM6B CSNK2B human exp
O15054 O15054 O75840 KDM6B KLF7 human pred
O15054 O15054 Q9UBB5 KDM6B MBD2 human pred
O15054 O15054 P48431 KDM6B SOX2 human exp
O15054 O15054 Q5JT82 KDM6B KLF17 human pred
O15054 O15054 Q13569 KDM6B TDG human exp
O15054 O15054 Q99612 KDM6B KLF6 human pred
O15054 O15054 P03372 KDM6B ESR1 human exp
O15054 O15054 Q04726 KDM6B TLE3 human pred
O15054 O15054 P04183 KDM6B TK1 human exp
O15054 O15054 Q9UBL3 KDM6B ASH2L human exp
O15054 O15054 Q15797 KDM6B SMAD1 human exp
O15054 O15054 P68431 KDM6B HIST1H3A human exp
O15054 O15054 P42768 KDM6B WAS human exp
O15054 O15054 Q9Y4C1 KDM6B KDM3A human pred
O15054 O15054 P61964 KDM6B WDR5 human exp
O15054 O15054 Q12899 KDM6B TRIM26 human ortho
O15054 O15054 Q9BVI0 KDM6B PHF20 human ortho
O15054 O15054 P51532 KDM6B SMARCA4 human ortho
O15054 O15054 Q15291 KDM6B RBBP5 human exp,ortho,pred
O15054 O15054 O43474 KDM6B KLF4 human exp
O15054 O15054 Q13485 KDM6B SMAD4 human exp
O15054 O15054 Q15796 KDM6B SMAD2 human exp
O15054 O15054 Q92922 KDM6B SMARCC1 human ortho
O15054 O15054 P08047 KDM6B SP1 human pred
O15054 O15054 Q9UGL1 KDM6B KDM5B human pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.