Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:


Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues




Results exceeding 3000 interactions will be returned as a downloadable file
  


Results

Retrieved 346 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
O43684 O43684 P08579 BUB3 SNRPB2 human pred
O43684 O43684 Q49MG5 BUB3 MAP9 human pred
O43684 O43684 P10827 BUB3 THRA human exp
O43684 O43684 O43264 BUB3 ZW10 human pred
O43684 O43684 P45973 BUB3 CBX5 human pred
O43684 O43684 P12004 BUB3 PCNA human pred
O43684 O43684 Q14980 BUB3 NUMA1 human pred
O43684 O43684 P62310 BUB3 LSM3 human pred
O43684 O43684 Q99459 BUB3 CDC5L human exp
O43684 O43684 P49736 BUB3 MCM2 human exp
O43684 O43684 O60671 BUB3 RAD1 human pred
O43684 O43684 Q9UMS4 BUB3 PRPF19 human pred
O43684 O43684 Q6PCD5 BUB3 RFWD3 human pred
O43684 O43684 Q9UM11 BUB3 FZR1 human pred
O43684 O43684 Q15717 BUB3 ELAVL1 human exp
O43684 O43684 P25787 BUB3 PSMA2 human pred
O43684 O43684 Q9Y4K3 BUB3 TRAF6 human exp
O43684 O43684 Q9Y265 BUB3 RUVBL1 human pred
O43684 O43684 P50748 BUB3 KNTC1 human pred
O43684 O43684 Q71F23 BUB3 CENPU human pred
O43684 O43684 P63165 BUB3 SUMO1 human pred
O43684 O43684 Q96RT8 BUB3 TUBGCP5 human pred
O43684 O43684 Q9UJX4 BUB3 ANAPC5 human exp
O43684 O43684 Q8WXA9 BUB3 SREK1 human pred
O43684 O43684 P43034 BUB3 PAFAH1B1 human pred
O43684 O43684 Q8TF05 BUB3 PPP4R1 human pred
O43684 O43684 Q9H410 BUB3 DSN1 human pred
O43684 O43684 O43592 BUB3 XPOT human pred
O43684 O43684 P20248 BUB3 CCNA2 human pred
O43684 O43684 O00139 BUB3 KIF2A human pred
O43684 O43684 P07910 BUB3 HNRNPC human pred
O43684 O43684 P52597 BUB3 HNRNPF human pred
O43684 O43684 Q99832 BUB3 CCT7 human exp
O43684 O43684 O95149 BUB3 SNUPN human pred
O43684 O43684 Q9BW19 BUB3 KIFC1 human pred
O43684 O43684 P78371 BUB3 CCT2 human exp,pred
O43684 O43684 Q99829 BUB3 CPNE1 human exp
O43684 O43684 Q8NI77 BUB3 KIF18A human pred
O43684 O43684 Q14203 BUB3 DCTN1 human pred
O43684 O43684 Q9NQ48 BUB3 LZTFL1 human exp
O43684 O43684 O60293 BUB3 ZFC3H1 human exp
O43684 O43684 P25788 BUB3 PSMA3 human pred
O43684 O43684 Q9NQZ2 BUB3 UTP3 human pred
O43684 O43684 P13010 BUB3 XRCC5 human pred
O43684 O43684 P25789 BUB3 PSMA4 human pred
O43684 O43684 O60506 BUB3 SYNCRIP human pred
O43684 O43684 P62314 BUB3 SNRPD1 human pred
O43684 O43684 Q13490 BUB3 BIRC2 human ortho
O43684 O43684 P49368 BUB3 CCT3 human pred
O43684 O43684 Q5FBB7 BUB3 SGO1 human pred
O43684 O43684 O43670 BUB3 ZNF207 human exp,pred
O43684 O43684 Q13618 BUB3 CUL3 human exp
O43684 O43684 Q9UKX2 BUB3 MYH2 human pred
O43684 O43684 Q04837 BUB3 SSBP1 human pred
O43684 O43684 P63010 BUB3 AP2B1 human pred
O43684 O43684 Q9H900 BUB3 ZWILCH human pred
O43684 O43684 Q9H8V3 BUB3 ECT2 human pred
O43684 O43684 P49715 BUB3 CEBPA human ortho
O43684 O43684 Q9NYP9 BUB3 MIS18A human pred
O43684 O43684 Q8N5F7 BUB3 NKAP human exp
O43684 O43684 O60645 BUB3 EXOC3 human exp
O43684 O43684 Q15388 BUB3 TOMM20 human pred
O43684 O43684 Q96A00 BUB3 PPP1R14A human pred
O43684 O43684 P51965 BUB3 UBE2E1 human pred
O43684 O43684 O43390 BUB3 HNRNPR human pred
O43684 O43684 Q9Y266 BUB3 NUDC human pred
O43684 O43684 P05114 BUB3 HMGN1 human pred
O43684 O43684 P27695 BUB3 APEX1 human exp
O43684 O43684 P83916 BUB3 CBX1 human pred
O43684 O43684 P00533 BUB3 EGFR human exp
O43684 O43684 Q9P1Y5 BUB3 CAMSAP3 human pred
O43684 O43684 Q15013 BUB3 MAD2L1BP human pred
O43684 O43684 P78406 BUB3 RAE1 human exp
O43684 O43684 Q7Z6Z7 BUB3 HUWE1 human exp
O43684 O43684 O43504 BUB3 LAMTOR5 human pred
O43684 O43684 Q96CS2 BUB3 HAUS1 human pred
O43684 O43684 Q96H22 BUB3 CENPN human pred
O43684 O43684 O43283 BUB3 MAP3K13 human pred
O43684 O43684 O00762 BUB3 UBE2C human pred
O43684 O43684 P08754 BUB3 GNAI3 human pred
O43684 O43684 Q9UBE0 BUB3 SAE1 human pred
O43684 O43684 Q15398 BUB3 DLGAP5 human pred
O43684 O43684 Q9UH99 BUB3 SUN2 human pred
O43684 O43684 Q8NG31 BUB3 KNL1 human pred
O43684 O43684 P53618 BUB3 COPB1 human pred
O43684 O43684 O75554 BUB3 WBP4 human exp
O43684 O43684 Q96IF1 BUB3 AJUBA human pred
O43684 O43684 Q8WXX5 BUB3 DNAJC9 human pred
O43684 O43684 O75122 BUB3 CLASP2 human pred
O43684 O43684 Q9H4L7 BUB3 SMARCAD1 human pred
O43684 O43684 Q13042 BUB3 CDC16 human exp,pred
O43684 O43684 P35244 BUB3 RPA3 human exp
O43684 O43684 Q15003 BUB3 NCAPH human pred
O43684 O43684 A4D177 BUB3 - human pred
O43684 O43684 P33316 BUB3 DUT human pred
O43684 O43684 Q96DE5 BUB3 ANAPC16 human exp
O43684 O43684 Q9C005 BUB3 DPY30 human pred
O43684 O43684 Q9UBP0 BUB3 - human pred
O43684 O43684 O60832 BUB3 DKC1 human pred
O43684 O43684 P38398 BUB3 BRCA1 human pred
O43684 O43684 O95071 BUB3 UBR5 human exp
O43684 O43684 P55036 BUB3 PSMD4 human pred
O43684 O43684 Q9BSJ2 BUB3 TUBGCP2 human pred
O43684 O43684 Q8WVM7 BUB3 STAG1 human pred
O43684 O43684 P07199 BUB3 CENPB human pred
O43684 O43684 O75436 BUB3 VPS26A human pred
O43684 O43684 Q04760 BUB3 GLO1 human pred
O43684 O43684 Q9NTJ3 BUB3 SMC4 human pred
O43684 O43684 O95613 BUB3 PCNT human pred
O43684 O43684 O14730 BUB3 RIOK3 human pred
O43684 O43684 P29218 BUB3 IMPA1 human pred
O43684 O43684 P35268 BUB3 RPL22 human pred
O43684 O43684 Q9BXF3 BUB3 CECR2 human pred
O43684 O43684 Q8N2Z9 BUB3 APITD1 human pred
O43684 O43684 Q8N6R0 BUB3 METTL13 human exp
O43684 O43684 Q53HL2 BUB3 CDCA8 human pred
O43684 O43684 Q13547 BUB3 HDAC1 human exp
O43684 O43684 P61758 BUB3 VBP1 human pred
O43684 O43684 Q9Y6D9 BUB3 MAD1L1 human pred
O43684 O43684 Q15019 BUB3 SEPT2 human exp
O43684 O43684 Q9UJX2 BUB3 CDC23 human exp,pred
O43684 O43684 O43683 BUB3 BUB1 human exp,pred
O43684 O43684 P63096 BUB3 GNAI1 human pred
O43684 O43684 Q15022 BUB3 SUZ12 human pred
O43684 O43684 P06748 BUB3 NPM1 human pred
O43684 O43684 P78527 BUB3 PRKDC human pred
O43684 O43684 P81274 BUB3 GPSM2 human pred
O43684 O43684 P53611 BUB3 RABGGTB human pred
O43684 O43684 P52292 BUB3 KPNA2 human pred
O43684 O43684 Q15041 BUB3 ARL6IP1 human pred
O43684 O43684 P22314 BUB3 UBA1 human exp
O43684 O43684 Q15796 BUB3 SMAD2 human exp
O43684 O43684 P35659 BUB3 DEK human pred
O43684 O43684 P11488 BUB3 GNAT1 human pred
O43684 O43684 Q9GZM8 BUB3 NDEL1 human pred
O43684 O43684 P19338 BUB3 NCL human pred
O43684 O43684 O15205 BUB3 UBD human pred
O43684 O43684 P55735 BUB3 SEC13 human pred
O43684 O43684 Q9HC77 BUB3 CENPJ human pred
O43684 O43684 Q9BVA0 BUB3 KATNB1 human pred
O43684 O43684 P53041 BUB3 PPP5C human ortho
O43684 O43684 O95229 BUB3 ZWINT human pred
O43684 O43684 P19086 BUB3 GNAZ human pred
O43684 O43684 O95072 BUB3 REC8 human pred
O43684 O43684 Q9H081 BUB3 MIS12 human pred
O43684 O43684 Q2NKX8 BUB3 ERCC6L human pred
O43684 O43684 Q53EZ4 BUB3 CEP55 human pred
O43684 O43684 Q9H3R5 BUB3 CENPH human pred
O43684 O43684 Q9BS16 BUB3 CENPK human pred
O43684 O43684 P57740 BUB3 NUP107 human pred
O43684 O43684 O15287 BUB3 FANCG human pred
O43684 O43684 O75177 BUB3 SS18L1 human pred
O43684 O43684 Q13352 BUB3 ITGB3BP human pred
O43684 O43684 O60216 BUB3 RAD21 human pred
O43684 O43684 P52789 BUB3 HK2 human exp
O43684 O43684 P05412 BUB3 JUN human exp
O43684 O43684 O43482 BUB3 OIP5 human pred
O43684 O43684 P49755 BUB3 TMED10 human pred
O43684 O43684 Q02224 BUB3 CENPE human pred
O43684 O43684 Q92674 BUB3 CENPI human pred
O43684 O43684 Q92905 BUB3 COPS5 human exp,pred
O43684 O43684 P30291 BUB3 WEE1 human pred
O43684 O43684 P22626 BUB3 HNRNPA2B1 human pred
O43684 O43684 Q9NSP4 BUB3 CENPM human pred
O43684 O43684 Q15691 BUB3 MAPRE1 human pred
O43684 O43684 O14980 BUB3 XPO1 human exp,pred
O43684 O43684 Q9UGN5 BUB3 PARP2 human exp,pred
O43684 O43684 Q9NVJ2 BUB3 ARL8B human pred
O43684 O43684 P30260 BUB3 CDC27 human exp,pred
O43684 O43684 P30153 BUB3 PPP2R1A human pred
O43684 O43684 P22234 BUB3 PAICS human pred
O43684 O43684 P36873 BUB3 PPP1CC human pred
O43684 O43684 Q96EE3 BUB3 SEH1L human pred
O43684 O43684 P49454 BUB3 CENPF human exp,pred
O43684 O43684 O94782 BUB3 USP1 human pred
O43684 O43684 P26583 BUB3 HMGB2 human pred
O43684 O43684 Q9H492 BUB3 MAP1LC3A human exp
O43684 O43684 O14530 BUB3 TXNDC9 human pred
O43684 O43684 Q15058 BUB3 KIF14 human pred
O43684 O43684 O43660 BUB3 PLRG1 human pred
O43684 O43684 Q9BV73 BUB3 CEP250 human pred
O43684 O43684 Q8IZT6 BUB3 ASPM human pred
O43684 O43684 O75832 BUB3 PSMD10 human pred
O43684 O43684 O60762 BUB3 DPM1 human pred
O43684 O43684 O43586 BUB3 PSTPIP1 human exp
O43684 O43684 Q15287 BUB3 RNPS1 human exp,pred
O43684 O43684 Q9UKT4 BUB3 FBXO5 human pred
O43684 O43684 O43566 BUB3 RGS14 human pred
O43684 O43684 Q9Y2Z0 BUB3 SUGT1 human exp,pred
O43684 O43684 O75916 BUB3 RGS9 human pred
O43684 O43684 Q9UBT2 BUB3 UBA2 human pred
O43684 O43684 P51955 BUB3 NEK2 human pred
O43684 O43684 P61978 BUB3 HNRNPK human pred
O43684 O43684 P84022 BUB3 SMAD3 human exp
O43684 O43684 Q9UGJ1 BUB3 TUBGCP4 human pred
O43684 O43684 O43143 BUB3 DHX15 human pred
O43684 O43684 P25054 BUB3 APC human exp,pred
O43684 O43684 Q9H0R8 BUB3 GABARAPL1 human exp
O43684 O43684 Q9HD67 BUB3 MYO10 human pred
O43684 O43684 Q8NBT2 BUB3 SPC24 human pred
O43684 O43684 O00541 BUB3 PES1 human exp,pred
O43684 O43684 Q93009 BUB3 USP7 human exp
O43684 O43684 Q71UI9 BUB3 H2AFV human pred
O43684 O43684 P14635 BUB3 CCNB1 human pred
O43684 O43684 P68431 BUB3 HIST1H3A human exp
O43684 O43684 Q969U7 BUB3 PSMG2 human pred
O43684 O43684 P48643 BUB3 CCT5 human exp
O43684 O43684 O75530 BUB3 EED human ortho,pred
O43684 O43684 P27816 BUB3 MAP4 human pred
O43684 O43684 Q8NHZ8 BUB3 CDC26 human exp
O43684 O43684 Q14137 BUB3 BOP1 human exp,pred
O43684 O43684 P19320 BUB3 VCAM1 human exp
O43684 O43684 Q9UI95 BUB3 MAD2L2 human pred
O43684 O43684 Q13185 BUB3 CBX3 human pred
O43684 O43684 P02751 BUB3 FN1 human exp
O43684 O43684 P51784 BUB3 USP11 human exp
O43684 O43684 P67809 BUB3 YBX1 human exp
O43684 O43684 P84103 BUB3 SRSF3 human pred
O43684 O43684 P50991 BUB3 CCT4 human exp
O43684 O43684 P23921 BUB3 RRM1 human pred
O43684 O43684 O75794 BUB3 CDC123 human pred
O43684 O43684 Q8WYP5 BUB3 AHCTF1 human pred
O43684 O43684 P50548 BUB3 ERF human pred
O43684 O43684 P51808 BUB3 DYNLT3 human exp,ortho,pred
O43684 O43684 Q96ST3 BUB3 SIN3A human pred
O43684 O43684 Q13487 BUB3 SNAPC2 human pred
O43684 O43684 P51858 BUB3 HDGF human exp
O43684 O43684 P30622 BUB3 CLIP1 human exp
O43684 O43684 P09001 BUB3 MRPL3 human pred
O43684 O43684 P61160 BUB3 ACTR2 human pred
O43684 O43684 Q9UQE7 BUB3 SMC3 human pred
O43684 O43684 Q9BUL8 BUB3 PDCD10 human pred
O43684 O43684 Q9UJX3 BUB3 ANAPC7 human pred
O43684 O43684 Q13148 BUB3 TARDBP human pred
O43684 O43684 P51668 BUB3 UBE2D1 human pred
O43684 O43684 P09874 BUB3 PARP1 human exp,pred
O43684 O43684 Q7Z5K2 BUB3 WAPL human pred
O43684 O43684 Q1MSJ5 BUB3 CSPP1 human pred
O43684 O43684 O60566 BUB3 BUB1B human exp,pred
O43684 O43684 P33981 BUB3 TTK human exp,pred
O43684 O43684 Q9BSF8 BUB3 BTBD10 human exp
O43684 O43684 Q03188 BUB3 CENPC human ortho
O43684 O43684 Q9NXR1 BUB3 NDE1 human pred
O43684 O43684 Q9GZQ8 BUB3 MAP1LC3B human exp
O43684 O43684 P08151 BUB3 GLI1 human exp
O43684 O43684 P52732 BUB3 KIF11 human pred
O43684 O43684 O76070 BUB3 SNCG human pred
O43684 O43684 P48730 BUB3 CSNK1D human pred
O43684 O43684 Q13564 BUB3 NAE1 human pred
O43684 O43684 P13612 BUB3 ITGA4 human exp
O43684 O43684 Q9H3N1 BUB3 TMX1 human pred
O43684 O43684 Q9Y6X3 BUB3 MAU2 human pred
O43684 O43684 P61163 BUB3 ACTR1A human pred
O43684 O43684 Q96B26 BUB3 EXOSC8 human pred
O43684 O43684 Q9UIF3 BUB3 TEKT2 human pred
O43684 O43684 Q16531 BUB3 DDB1 human pred
O43684 O43684 Q8WZ42 BUB3 TTN human pred
O43684 O43684 Q7Z460 BUB3 CLASP1 human pred
O43684 O43684 P06493 BUB3 CDK1 human pred
O43684 O43684 Q14978 BUB3 NOLC1 human pred
O43684 O43684 Q8NFH3 BUB3 NUP43 human pred
O43684 O43684 Q9UJX5 BUB3 ANAPC4 human exp
O43684 O43684 Q15185 BUB3 PTGES3 human pred
O43684 O43684 P50990 BUB3 CCT8 human pred
O43684 O43684 Q13216 BUB3 ERCC8 human pred
O43684 O43684 Q12824 BUB3 SMARCB1 human pred
O43684 O43684 P41208 BUB3 CETN2 human pred
O43684 O43684 P11171 BUB3 EPB41 human pred
O43684 O43684 Q16584 BUB3 MAP3K11 human pred
O43684 O43684 P50570 BUB3 DNM2 human exp
O43684 O43684 Q14674 BUB3 ESPL1 human pred
O43684 O43684 Q9Y6A5 BUB3 TACC3 human pred
O43684 O43684 Q13283 BUB3 G3BP1 human pred
O43684 O43684 P0C0S5 BUB3 H2AFZ human pred
O43684 O43684 Q9NVH2 BUB3 INTS7 human exp
O43684 O43684 Q9UKK6 BUB3 NXT1 human pred
O43684 O43684 Q9H1A4 BUB3 ANAPC1 human exp
O43684 O43684 Q15154 BUB3 PCM1 human pred
O43684 O43684 Q9UKE5 BUB3 TNIK human exp
O43684 O43684 P61513 BUB3 RPL37A human exp
O43684 O43684 Q14008 BUB3 CKAP5 human pred
O43684 O43684 P52907 BUB3 CAPZA1 human pred
O43684 O43684 P61158 BUB3 ACTR3 human pred
O43684 O43684 Q9Y5J1 BUB3 UTP18 human pred
O43684 O43684 Q96S59 BUB3 RANBP9 human pred
O43684 O43684 Q1MX18 BUB3 INSC human pred
O43684 O43684 Q15021 BUB3 NCAPD2 human pred
O43684 O43684 O75116 BUB3 ROCK2 human pred
O43684 O43684 Q9Y297 BUB3 BTRC human pred
O43684 O43684 P36404 BUB3 ARL2 human pred
O43684 O43684 P27694 BUB3 RPA1 human exp,pred
O43684 O43684 Q9HBM1 BUB3 SPC25 human pred
O43684 O43684 Q8N3U4 BUB3 STAG2 human pred
O43684 O43684 Q96IY1 BUB3 NSL1 human pred
O43684 O43684 Q02241 BUB3 KIF23 human pred
O43684 O43684 O60934 BUB3 NBN human pred
O43684 O43684 O96017 BUB3 CHEK2 human exp
O43684 O43684 P62140 BUB3 PPP1CB human pred
O43684 O43684 Q96CW5 BUB3 TUBGCP3 human pred
O43684 O43684 Q8WUM0 BUB3 NUP133 human pred
O43684 O43684 P53999 BUB3 SUB1 human pred
O43684 O43684 Q9ULW0 BUB3 TPX2 human pred
O43684 O43684 Q15428 BUB3 SF3A2 human exp
O43684 O43684 Q7L2H7 BUB3 EIF3M human pred
O43684 O43684 Q07955 BUB3 SRSF1 human pred
O43684 O43684 Q9BZD4 BUB3 NUF2 human pred
O43684 O43684 Q13573 BUB3 SNW1 human exp
O43684 O43684 Q09028 BUB3 RBBP4 human pred
O43684 O43684 Q14444 BUB3 CAPRIN1 human pred
O43684 O43684 Q969G3 BUB3 SMARCE1 human pred
O43684 O43684 P49450 BUB3 CENPA human pred
O43684 O43684 O00487 BUB3 PSMD14 human pred
O43684 O43684 P11387 BUB3 TOP1 human exp
O43684 O43684 Q9BU64 BUB3 CENPO human pred
O43684 O43684 Q7Z5Y7 BUB3 KCTD20 human exp
O43684 O43684 Q01105 BUB3 SET human pred
O43684 O43684 Q16186 BUB3 ADRM1 human exp
O43684 O43684 P04629 BUB3 NTRK1 human exp
O43684 O43684 Q2LD37 BUB3 KIAA1109 human exp
O43684 O43684 P30876 BUB3 POLR2B human pred
O43684 O43684 Q8NFH4 BUB3 NUP37 human pred
O43684 O43684 Q9H0E7 BUB3 USP44 human pred
O43684 O43684 Q92769 BUB3 HDAC2 human exp,pred
O43684 O43684 Q9BW27 BUB3 NUP85 human pred
O43684 O43684 Q13257 BUB3 MAD2L1 human exp,pred
O43684 O43684 Q6IPU0 BUB3 CENPP human pred
O43684 O43684 Q14974 BUB3 KPNB1 human exp
O43684 O43684 Q96BM9 BUB3 ARL8A human pred
O43684 O43684 P51587 BUB3 BRCA2 human pred
O43684 O43684 Q96Q89 BUB3 KIF20B human pred
O43684 O43684 Q01130 BUB3 SRSF2 human pred
O43684 O43684 O14776 BUB3 TCERG1 human pred
O43684 O43684 Q8N0S6 BUB3 CENPL human pred
O43684 O43684 Q5U651 BUB3 RASIP1 human exp
O43684 O43684 P61289 BUB3 PSME3 human pred
O43684 O43684 Q99996 BUB3 AKAP9 human pred
O43684 O43684 Q96GD4 BUB3 AURKB human pred
O43684 O43684 Q7L2Z9 BUB3 CENPQ human pred
O43684 O43684 P05106 BUB3 ITGB3 human pred
O43684 O43684 Q96R06 BUB3 SPAG5 human pred
O43684 O43684 Q6NXT2 BUB3 H3F3C human pred
O43684 O43684 P62258 BUB3 YWHAE human ortho
O43684 O43684 P15927 BUB3 RPA2 human exp
O43684 O43684 Q15555 BUB3 MAPRE2 human pred
O43684 O43684 Q12834 BUB3 CDC20 human exp,pred
O43684 O43684 Q96BT3 BUB3 CENPT human pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.