Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 24 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
O75936 O75936 A0MZ66 BBOX1 SHTN1 human exp
O75936 O75936 P02766 BBOX1 TTR human pred
O75936 O75936 P00966 BBOX1 ASS1 human pred
O75936 O75936 Q8N3K9 BBOX1 CMYA5 human pred
O75936 O75936 O75936 BBOX1 BBOX1 human exp,pred
O75936 O75936 Q9H1D9 BBOX1 POLR3F human exp
O75936 O75936 Q14573 BBOX1 ITPR3 human exp
O75936 O75936 Q9NVH6 BBOX1 TMLHE human pred
O75936 O75936 Q9H6S1 BBOX1 AZI2 human exp
O75936 O75936 Q9UHD2 BBOX1 TBK1 human exp
O75936 O75936 O95336 BBOX1 PGLS human ortho
O75936 O75936 Q12988 BBOX1 HSPB3 human exp
O75936 O75936 Q92844 BBOX1 TANK human exp
O75936 O75936 P47813 BBOX1 EIF1AX human exp
O75936 O75936 Q6FI81 BBOX1 CIAPIN1 human exp
O75936 O75936 Q16878 BBOX1 CDO1 human pred
O75936 O75936 P28290 BBOX1 SSFA2 human exp
O75936 O75936 Q14571 BBOX1 ITPR2 human exp
O75936 O75936 P42575 BBOX1 CASP2 human exp
O75936 O75936 P40222 BBOX1 TXLNA human exp
O75936 O75936 Q13137 BBOX1 CALCOCO2 human exp
O75936 O75936 P57721 BBOX1 PCBP3 human exp
O75936 O75936 O60260 BBOX1 PRKN human exp
O75936 O75936 Q9BY42 BBOX1 RTFDC1 human exp

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.