Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 9 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
O76090 O76090 P32243 BEST1 OTX2 human pred
O76090 O76090 Q15172 BEST1 PPP2R5A human exp,pred
O76090 O76090 Q9UHW9 BEST1 SLC12A6 human pred
O76090 O76090 O76090 BEST1 BEST1 human exp,ortho
O76090 O76090 P67775 BEST1 PPP2CA human exp
O76090 O76090 P39748 BEST1 FEN1 human pred
O76090 O76090 O43186 BEST1 CRX human pred
O76090 O76090 P23942 BEST1 PRPH2 human pred
O76090 O76090 P55011 BEST1 SLC12A2 human pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.