Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 20 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
O94844 O94844 Q7L5N1 RHOBTB1 COPS6 human exp
O94844 O94844 P49674 RHOBTB1 CSNK1E human exp
O94844 O94844 Q92905 RHOBTB1 COPS5 human exp
O94844 O94844 Q15796 RHOBTB1 SMAD2 human exp
O94844 O94844 P36897 RHOBTB1 TGFBR1 human exp
O94844 O94844 O14641 RHOBTB1 DVL2 human exp
O94844 O94844 P11161 RHOBTB1 EGR2 human pred
O94844 O94844 P48729 RHOBTB1 CSNK1A1 human exp
O94844 O94844 Q8WYP3 RHOBTB1 RIN2 human pred
O94844 O94844 Q9Y2T1 RHOBTB1 AXIN2 human exp
O94844 O94844 Q93034 RHOBTB1 CUL5 human exp
O94844 O94844 Q04771 RHOBTB1 ACVR1 human exp
O94844 O94844 Q13618 RHOBTB1 CUL3 human exp
O94844 O94844 O00238 RHOBTB1 BMPR1B human exp
O94844 O94844 P08238 RHOBTB1 HSP90AB1 human exp
O94844 O94844 Q14CS0 RHOBTB1 UBXN2B human pred
O94844 O94844 P07900 RHOBTB1 HSP90AA1 human exp
O94844 O94844 Q13671 RHOBTB1 RIN1 human pred
O94844 O94844 Q15797 RHOBTB1 SMAD1 human exp
O94844 O94844 Q9Y696 RHOBTB1 CLIC4 human pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.