Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 20 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
P02100 P02100 P69892 HBE1 HBG2 human pred
P02100 P02100 P21860 HBE1 ERBB3 human exp
P02100 P02100 Q9NPG2 HBE1 NGB human pred
P02100 P02100 Q6B0K9 HBE1 HBM human pred
P02100 P02100 Q8WWM9 HBE1 CYGB human pred
P02100 P02100 P19320 HBE1 VCAM1 human exp
P02100 P02100 P35558 HBE1 PCK1 human pred
P02100 P02100 Q8WWN9 HBE1 IPCEF1 human pred
P02100 P02100 P13612 HBE1 ITGA4 human exp
P02100 P02100 P09105 HBE1 HBQ1 human pred
P02100 P02100 Q9BQ69 HBE1 MACROD1 human exp
P02100 P02100 P69905 HBE1 HBA1 human exp,pred
P02100 P02100 P02042 HBE1 HBD human pred
P02100 P02100 Q9NZD4 HBE1 AHSP human pred
P02100 P02100 P68871 HBE1 HBB human exp,pred
P02100 P02100 P02100 HBE1 HBE1 human pred
P02100 P02100 P02008 HBE1 HBZ human exp,pred
P02100 P02100 P02144 HBE1 MB human pred
P02100 P02100 Q658Y4 HBE1 FAM91A1 human pred
P02100 P02100 P69891 HBE1 HBG1 human pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.