Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:


Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues




Results exceeding 3000 interactions will be returned as a downloadable file
  


Results

Retrieved 351 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
P05783 P05783 O15027 KRT18 SEC16A human exp
P05783 P05783 Q13501 KRT18 SQSTM1 human ortho
P05783 P05783 P22681 KRT18 CBL human exp,pred
P05783 P05783 Q13177 KRT18 PAK2 human pred
P05783 P05783 P11021 KRT18 HSPA5 human exp,pred
P05783 P05783 P16144 KRT18 ITGB4 human pred
P05783 P05783 O75190 KRT18 DNAJB6 human exp
P05783 P05783 Q14790 KRT18 CASP8 human exp,pred
P05783 P05783 Q00688 KRT18 FKBP3 human exp
P05783 P05783 P08670 KRT18 VIM human pred
P05783 P05783 Q00537 KRT18 CDK17 human pred
P05783 P05783 Q15831 KRT18 STK11 human pred
P05783 P05783 P11142 KRT18 HSPA8 human pred
P05783 P05783 O75618 KRT18 DEDD human exp
P05783 P05783 P33176 KRT18 KIF5B human pred
P05783 P05783 P29353 KRT18 SHC1 human exp
P05783 P05783 P51812 KRT18 RPS6KA3 human exp,pred
P05783 P05783 P06400 KRT18 RB1 human pred
P05783 P05783 O43524 KRT18 FOXO3 human pred
P05783 P05783 Q969H4 KRT18 CNKSR1 human pred
P05783 P05783 Q14999 KRT18 CUL7 human exp
P05783 P05783 P23508 KRT18 MCC human exp
P05783 P05783 Q9P0K1 KRT18 ADAM22 human pred
P05783 P05783 O14745 KRT18 SLC9A3R1 human pred
P05783 P05783 Q92499 KRT18 DDX1 human exp
P05783 P05783 P05114 KRT18 HMGN1 human pred
P05783 P05783 Q9BT92 KRT18 TCHP human exp
P05783 P05783 Q02241 KRT18 KIF23 human pred
P05783 P05783 P15924 KRT18 DSP human exp,pred
P05783 P05783 P17252 KRT18 PRKCA human exp,pred
P05783 P05783 P06733 KRT18 ENO1 human pred
P05783 P05783 P68104 KRT18 EEF1A1 human pred
P05783 P05783 Q9Y2W1 KRT18 THRAP3 human pred
P05783 P05783 Q08379 KRT18 GOLGA2 human exp
P05783 P05783 Q9UQ35 KRT18 SRRM2 human pred
P05783 P05783 Q86X29 KRT18 LSR human pred
P05783 P05783 Q8IX03 KRT18 WWC1 human pred
P05783 P05783 P98082 KRT18 DAB2 human pred
P05783 P05783 Q13427 KRT18 PPIG human pred
P05783 P05783 Q15349 KRT18 RPS6KA2 human pred
P05783 P05783 Q3SYG4 KRT18 BBS9 human pred
P05783 P05783 P27448 KRT18 MARK3 human pred
P05783 P05783 P31947 KRT18 SFN human pred
P05783 P05783 P45983 KRT18 MAPK8 human pred
P05783 P05783 Q14094 KRT18 CCNI human exp
P05783 P05783 Q14978 KRT18 NOLC1 human pred
P05783 P05783 P15311 KRT18 EZR human pred
P05783 P05783 P05452 KRT18 CLEC3B human exp
P05783 P05783 P58107 KRT18 EPPK1 human pred
P05783 P05783 P02792 KRT18 FTL human pred
P05783 P05783 Q9UPT5 KRT18 EXOC7 human pred
P05783 P05783 Q09472 KRT18 EP300 human exp
P05783 P05783 O15551 KRT18 CLDN3 human pred
P05783 P05783 P27348 KRT18 YWHAQ human exp,pred
P05783 P05783 P30307 KRT18 CDC25C human pred
P05783 P05783 Q504Y2 KRT18 PKDCC human pred
P05783 P05783 P46937 KRT18 YAP1 human pred
P05783 P05783 P23528 KRT18 CFL1 human pred
P05783 P05783 O95471 KRT18 CLDN7 human pred
P05783 P05783 O95994 KRT18 AGR2 human pred
P05783 P05783 Q9UM73 KRT18 ALK human exp
P05783 P05783 P04049 KRT18 RAF1 human exp,pred
P05783 P05783 P13612 KRT18 ITGA4 human exp
P05783 P05783 P49840 KRT18 GSK3A human pred
P05783 P05783 Q13322 KRT18 GRB10 human pred
P05783 P05783 P15941 KRT18 MUC1 human pred
P05783 P05783 O75530 KRT18 EED human exp,ortho
P05783 P05783 Q13835 KRT18 PKP1 human exp
P05783 P05783 Q8TEW0 KRT18 PARD3 human pred
P05783 P05783 P30086 KRT18 PEBP1 human pred
P05783 P05783 P55211 KRT18 CASP9 human pred
P05783 P05783 Q14161 KRT18 GIT2 human exp
P05783 P05783 O43278 KRT18 SPINT1 human pred
P05783 P05783 P20333 KRT18 TNFRSF1B human exp
P05783 P05783 P60568 KRT18 IL2 human pred
P05783 P05783 Q99959 KRT18 PKP2 human exp
P05783 P05783 O43291 KRT18 SPINT2 human pred
P05783 P05783 Q92851 KRT18 CASP10 human pred
P05783 P05783 P11388 KRT18 TOP2A human pred
P05783 P05783 Q9Y2J2 KRT18 EPB41L3 human pred
P05783 P05783 Q9UQM7 KRT18 CAMK2A human exp,pred
P05783 P05783 P02751 KRT18 FN1 human exp
P05783 P05783 Q14CN4 KRT18 KRT72 human exp
P05783 P05783 Q12774 KRT18 ARHGEF5 human pred
P05783 P05783 P15336 KRT18 ATF2 human exp
P05783 P05783 Q9UDY2 KRT18 TJP2 human pred
P05783 P05783 P05787 KRT18 KRT8 human exp,pred
P05783 P05783 P00533 KRT18 EGFR human exp,pred
P05783 P05783 Q96RK4 KRT18 BBS4 human exp,pred
P05783 P05783 P17096 KRT18 HMGA1 human pred
P05783 P05783 P35968 KRT18 KDR human pred
P05783 P05783 P07437 KRT18 TUBB human pred
P05783 P05783 Q96CS3 KRT18 FAF2 human exp
P05783 P05783 Q15154 KRT18 PCM1 human pred
P05783 P05783 P10275 KRT18 AR human pred
P05783 P05783 Q5PRF9 KRT18 SAMD4B human pred
P05783 P05783 O60282 KRT18 KIF5C human pred
P05783 P05783 P15056 KRT18 BRAF human pred
P05783 P05783 Q9H0X9 KRT18 OSBPL5 human pred
P05783 P05783 P46527 KRT18 CDKN1B human pred
P05783 P05783 Q9UBF8 KRT18 PI4KB human pred
P05783 P05783 P00519 KRT18 ABL1 human pred
P05783 P05783 Q6ICG6 KRT18 KIAA0930 human pred
P05783 P05783 Q8NFJ9 KRT18 BBS1 human exp,pred
P05783 P05783 Q96CS2 KRT18 HAUS1 human exp
P05783 P05783 Q05639 KRT18 EEF1A2 human pred
P05783 P05783 P61981 KRT18 YWHAG human exp,pred
P05783 P05783 O96013 KRT18 PAK4 human pred
P05783 P05783 Q16539 KRT18 MAPK14 human exp,pred
P05783 P05783 P21796 KRT18 VDAC1 human pred
P05783 P05783 Q13094 KRT18 LCP2 human pred
P05783 P05783 O60437 KRT18 PPL human pred
P05783 P05783 Q96MU7 KRT18 YTHDC1 human exp
P05783 P05783 P21580 KRT18 TNFAIP3 human pred
P05783 P05783 P37088 KRT18 SCNN1A human pred
P05783 P05783 Q9H2G9 KRT18 BLZF1 human pred
P05783 P05783 Q92574 KRT18 TSC1 human pred
P05783 P05783 P05062 KRT18 ALDOB human pred
P05783 P05783 O60674 KRT18 JAK2 human pred
P05783 P05783 Q06187 KRT18 BTK human pred
P05783 P05783 Q99816 KRT18 TSG101 human exp
P05783 P05783 Q9Y224 KRT18 C14orf166 human exp
P05783 P05783 O15530 KRT18 PDPK1 human pred
P05783 P05783 P02671 KRT18 FGA human exp
P05783 P05783 P31749 KRT18 AKT1 human pred
P05783 P05783 P35606 KRT18 COPB2 human pred
P05783 P05783 P19320 KRT18 VCAM1 human exp
P05783 P05783 P62158 KRT18 CALM1 human pred
P05783 P05783 Q9Y4H2 KRT18 IRS2 human pred
P05783 P05783 Q99459 KRT18 CDC5L human exp,pred
P05783 P05783 Q9Y6K9 KRT18 IKBKG human exp
P05783 P05783 Q96A00 KRT18 PPP1R14A human pred
P05783 P05783 Q504Q3 KRT18 PAN2 human exp
P05783 P05783 Q15628 KRT18 TRADD human exp,pred
P05783 P05783 P13647 KRT18 KRT5 human exp
P05783 P05783 Q8IUC4 KRT18 RHPN2 human exp
P05783 P05783 P98170 KRT18 XIAP human pred
P05783 P05783 P04406 KRT18 GAPDH human pred
P05783 P05783 P09913 KRT18 IFIT2 human exp
P05783 P05783 P98161 KRT18 PKD1 human exp
P05783 P05783 Q00839 KRT18 HNRNPU human exp
P05783 P05783 Q99814 KRT18 EPAS1 human pred
P05783 P05783 P56524 KRT18 HDAC4 human pred
P05783 P05783 P13569 KRT18 CFTR human exp
P05783 P05783 P20700 KRT18 LMNB1 human pred
P05783 P05783 P12644 KRT18 BMP4 human pred
P05783 P05783 Q9HC77 KRT18 CENPJ human pred
P05783 P05783 P16471 KRT18 PRLR human pred
P05783 P05783 P27986 KRT18 PIK3R1 human pred
P05783 P05783 O95751 KRT18 LDOC1 human exp
P05783 P05783 Q8IYI6 KRT18 EXOC8 human exp
P05783 P05783 P0DMV9 KRT18 HSPA1B human exp
P05783 P05783 Q8IXJ6 KRT18 SIRT2 human pred
P05783 P05783 Q86W92 KRT18 PPFIBP1 human pred
P05783 P05783 Q8N0S2 KRT18 SYCE1 human exp
P05783 P05783 Q13523 KRT18 PRPF4B human pred
P05783 P05783 Q92974 KRT18 ARHGEF2 human pred
P05783 P05783 P56945 KRT18 BCAR1 human pred
P05783 P05783 P05783 KRT18 KRT18 human exp
P05783 P05783 Q9Y5K6 KRT18 CD2AP human pred
P05783 P05783 O60716 KRT18 CTNND1 human pred
P05783 P05783 O95425 KRT18 SVIL human exp
P05783 P05783 O75955 KRT18 FLOT1 human pred
P05783 P05783 P35250 KRT18 RFC2 human exp
P05783 P05783 Q53ET0 KRT18 CRTC2 human pred
P05783 P05783 Q8IYE0 KRT18 CCDC146 human exp
P05783 P05783 Q8WUI4 KRT18 HDAC7 human pred
P05783 P05783 P31431 KRT18 SDC4 human pred
P05783 P05783 P08238 KRT18 HSP90AB1 human pred
P05783 P05783 Q5TCQ9 KRT18 MAGI3 human pred
P05783 P05783 Q13895 KRT18 BYSL human exp
P05783 P05783 Q02962 KRT18 PAX2 human pred
P05783 P05783 Q9BV36 KRT18 MLPH human pred
P05783 P05783 P23258 KRT18 TUBG1 human exp
P05783 P05783 P06748 KRT18 NPM1 human pred
P05783 P05783 O95238 KRT18 SPDEF human pred
P05783 P05783 Q9UQB8 KRT18 BAIAP2 human pred
P05783 P05783 Q05513 KRT18 PRKCZ human pred
P05783 P05783 P49736 KRT18 MCM2 human exp
P05783 P05783 Q05655 KRT18 PRKCD human pred
P05783 P05783 P32121 KRT18 ARRB2 human pred
P05783 P05783 Q8IWZ6 KRT18 BBS7 human exp,pred
P05783 P05783 Q9H307 KRT18 PNN human exp,pred
P05783 P05783 Q9NZ52 KRT18 GGA3 human pred
P05783 P05783 Q13043 KRT18 STK4 human pred
P05783 P05783 Q9H0B6 KRT18 KLC2 human pred
P05783 P05783 P38936 KRT18 CDKN1A human pred
P05783 P05783 P50613 KRT18 CDK7 human pred
P05783 P05783 O15360 KRT18 FANCA human pred
P05783 P05783 O00273 KRT18 DFFA human pred
P05783 P05783 P40818 KRT18 USP8 human pred
P05783 P05783 Q9Y3R5 KRT18 DOPEY2 human pred
P05783 P05783 P34932 KRT18 HSPA4 human exp
P05783 P05783 P29466 KRT18 CASP1 human pred
P05783 P05783 Q00536 KRT18 CDK16 human pred
P05783 P05783 P49662 KRT18 CASP4 human pred
P05783 P05783 P49407 KRT18 ARRB1 human pred
P05783 P05783 Q9NUX5 KRT18 POT1 human exp
P05783 P05783 Q96F86 KRT18 EDC3 human pred
P05783 P05783 P62993 KRT18 GRB2 human exp,pred
P05783 P05783 A5YKK6 KRT18 CNOT1 human exp
P05783 P05783 P16422 KRT18 EPCAM human pred
P05783 P05783 P19338 KRT18 NCL human pred
P05783 P05783 Q99759 KRT18 MAP3K3 human pred
P05783 P05783 O14493 KRT18 CLDN4 human pred
P05783 P05783 Q99757 KRT18 TXN2 human exp
P05783 P05783 O60825 KRT18 PFKFB2 human pred
P05783 P05783 Q9Y3I0 KRT18 RTCB human exp
P05783 P05783 P12830 KRT18 CDH1 human exp,pred
P05783 P05783 Q9H0W5 KRT18 CCDC8 human exp
P05783 P05783 O43707 KRT18 ACTN4 human pred
P05783 P05783 Q9BXC9 KRT18 BBS2 human exp,pred
P05783 P05783 Q00610 KRT18 CLTC human pred
P05783 P05783 P10398 KRT18 ARAF human pred
P05783 P05783 Q15139 KRT18 PRKD1 human pred
P05783 P05783 Q12802 KRT18 AKAP13 human pred
P05783 P05783 P62995 KRT18 TRA2B human pred
P05783 P05783 Q9UGJ1 KRT18 TUBGCP4 human exp
P05783 P05783 O95831 KRT18 AIFM1 human pred
P05783 P05783 O95373 KRT18 IPO7 human pred
P05783 P05783 Q6PKC3 KRT18 TXNDC11 human exp
P05783 P05783 P78527 KRT18 PRKDC human pred
P05783 P05783 P30305 KRT18 CDC25B human pred
P05783 P05783 O15392 KRT18 BIRC5 human pred
P05783 P05783 Q9Y446 KRT18 PKP3 human exp
P05783 P05783 P17861 KRT18 XBP1 human pred
P05783 P05783 Q96GM5 KRT18 SMARCD1 human exp
P05783 P05783 P19012 KRT18 KRT15 human exp
P05783 P05783 O75147 KRT18 OBSL1 human exp
P05783 P05783 Q9UK53 KRT18 ING1 human pred
P05783 P05783 Q8IWF2 KRT18 FOXRED2 human exp
P05783 P05783 P18031 KRT18 PTPN1 human pred
P05783 P05783 Q96QF0 KRT18 RAB3IP human pred
P05783 P05783 P35228 KRT18 NOS2 human exp
P05783 P05783 Q9HCU9 KRT18 BRMS1 human pred
P05783 P05783 Q6WCQ1 KRT18 MPRIP human pred
P05783 P05783 P49796 KRT18 RGS3 human pred
P05783 P05783 P10415 KRT18 BCL2 human pred
P05783 P05783 P23229 KRT18 ITGA6 human pred
P05783 P05783 P31946 KRT18 YWHAB human exp,pred
P05783 P05783 Q04912 KRT18 MST1R human pred
P05783 P05783 P26045 KRT18 PTPN3 human pred
P05783 P05783 Q9UKV3 KRT18 ACIN1 human pred
P05783 P05783 P28482 KRT18 MAPK1 human pred
P05783 P05783 Q13224 KRT18 GRIN2B human pred
P05783 P05783 Q13153 KRT18 PAK1 human pred
P05783 P05783 Q92934 KRT18 BAD human pred
P05783 P05783 Q9H0F7 KRT18 ARL6 human pred
P05783 P05783 Q13114 KRT18 TRAF3 human pred
P05783 P05783 P05067 KRT18 APP human pred
P05783 P05783 P14784 KRT18 IL2RB human pred
P05783 P05783 Q96PM5 KRT18 RCHY1 human exp
P05783 P05783 Q16651 KRT18 PRSS8 human pred
P05783 P05783 Q15287 KRT18 RNPS1 human pred
P05783 P05783 P49760 KRT18 CLK2 human pred
P05783 P05783 P55210 KRT18 CASP7 human exp
P05783 P05783 P06454 KRT18 PTMA human pred
P05783 P05783 Q99683 KRT18 MAP3K5 human pred
P05783 P05783 P30291 KRT18 WEE1 human pred
P05783 P05783 P04792 KRT18 HSPB1 human exp
P05783 P05783 P21860 KRT18 ERBB3 human pred
P05783 P05783 P02545 KRT18 LMNA human pred
P05783 P05783 P31785 KRT18 IL2RG human pred
P05783 P05783 P10809 KRT18 HSPD1 human pred
P05783 P05783 P62258 KRT18 YWHAE human exp,ortho,pred
P05783 P05783 P01106 KRT18 MYC human pred
P05783 P05783 Q9UBN7 KRT18 HDAC6 human pred
P05783 P05783 P03372 KRT18 ESR1 human exp
P05783 P05783 Q9H4A3 KRT18 WNK1 human pred
P05783 P05783 P68431 KRT18 HIST1H3A human exp
P05783 P05783 P11274 KRT18 BCR human pred
P05783 P05783 Q13546 KRT18 RIPK1 human pred
P05783 P05783 Q8IVT5 KRT18 KSR1 human pred
P05783 P05783 P63104 KRT18 YWHAZ human exp,ortho,pred
P05783 P05783 P01112 KRT18 HRAS human exp
P05783 P05783 O75445 KRT18 USH2A human exp
P05783 P05783 P04637 KRT18 TP53 human pred
P05783 P05783 P10636 KRT18 MAPT human pred
P05783 P05783 P08727 KRT18 KRT19 human pred
P05783 P05783 Q9Y5Y6 KRT18 ST14 human pred
P05783 P05783 Q02750 KRT18 MAP2K1 human pred
P05783 P05783 Q13045 KRT18 FLII human exp
P05783 P05783 P55317 KRT18 FOXA1 human pred
P05783 P05783 P28329 KRT18 CHAT human pred
P05783 P05783 P51572 KRT18 BCAP31 human pred
P05783 P05783 Q07021 KRT18 C1QBP human pred
P05783 P05783 Q8N2W9 KRT18 PIAS4 human exp
P05783 P05783 Q14203 KRT18 DCTN1 human pred
P05783 P05783 Q9P0K7 KRT18 RAI14 human pred
P05783 P05783 Q14814 KRT18 MEF2D human pred
P05783 P05783 O75558 KRT18 STX11 human pred
P05783 P05783 P63261 KRT18 ACTG1 human pred
P05783 P05783 P42574 KRT18 CASP3 human exp,pred
P05783 P05783 P46940 KRT18 IQGAP1 human pred
P05783 P05783 Q9NZQ3 KRT18 NCKIPSD human pred
P05783 P05783 O75369 KRT18 FLNB human pred
P05783 P05783 O95336 KRT18 PGLS human ortho
P05783 P05783 P08729 KRT18 KRT7 human pred
P05783 P05783 Q6PKG0 KRT18 LARP1 human pred
P05783 P05783 Q15078 KRT18 CDK5R1 human pred
P05783 P05783 P63167 KRT18 DYNLL1 human exp
P05783 P05783 P35579 KRT18 MYH9 human pred
P05783 P05783 O43390 KRT18 HNRNPR human exp
P05783 P05783 P02771 KRT18 AFP human pred
P05783 P05783 Q9Y5B8 KRT18 NME7 human exp
P05783 P05783 Q8NFA0 KRT18 USP32 human exp
P05783 P05783 P33992 KRT18 MCM5 human exp
P05783 P05783 Q8TAM2 KRT18 TTC8 human pred
P05783 P05783 O75674 KRT18 TOM1L1 human pred
P05783 P05783 Q9UMD9 KRT18 COL17A1 human exp,pred
P05783 P05783 P52292 KRT18 KPNA2 human exp
P05783 P05783 Q12778 KRT18 FOXO1 human pred
P05783 P05783 Q9HAU5 KRT18 UPF2 human exp
P05783 P05783 P30304 KRT18 CDC25A human pred
P05783 P05783 O75689 KRT18 ADAP1 human pred
P05783 P05783 Q9H2F3 KRT18 HSD3B7 human ortho
P05783 P05783 P14136 KRT18 GFAP human pred
P05783 P05783 Q96PU5 KRT18 NEDD4L human pred
P05783 P05783 Q9H0H5 KRT18 RACGAP1 human pred
P05783 P05783 P06493 KRT18 CDK1 human exp
P05783 P05783 Q02156 KRT18 PRKCE human exp,pred
P05783 P05783 Q15121 KRT18 PEA15 human pred
P05783 P05783 P07900 KRT18 HSP90AA1 human pred
P05783 P05783 O75688 KRT18 PPM1B human exp
P05783 P05783 O15519 KRT18 CFLAR human pred
P05783 P05783 Q9P1A6 KRT18 DLGAP2 human pred
P05783 P05783 Q15834 KRT18 CCDC85B human exp
P05783 P05783 Q15051 KRT18 IQCB1 human exp
P05783 P05783 Q9UBN6 KRT18 TNFRSF10D human pred
P05783 P05783 O60635 KRT18 TSPAN1 human pred
P05783 P05783 P29475 KRT18 NOS1 human pred
P05783 P05783 P05121 KRT18 SERPINE1 human exp
P05783 P05783 P84103 KRT18 SRSF3 human pred
P05783 P05783 Q12815 KRT18 TROAP human exp
P05783 P05783 P20941 KRT18 PDC human pred
P05783 P05783 P49815 KRT18 TSC2 human pred
P05783 P05783 Q92837 KRT18 FRAT1 human exp
P05783 P05783 P55212 KRT18 CASP6 human exp,pred
P05783 P05783 P49841 KRT18 GSK3B human pred
P05783 P05783 Q86X27 KRT18 RALGPS2 human pred
P05783 P05783 Q5VU43 KRT18 PDE4DIP human exp
P05783 P05783 O43913 KRT18 ORC5 human exp
P05783 P05783 P12814 KRT18 ACTN1 human pred
P05783 P05783 Q04917 KRT18 YWHAH human exp,pred
P05783 P05783 P28799 KRT18 GRN human exp
P05783 P05783 O95819 KRT18 MAP4K4 human exp
P05783 P05783 P50914 KRT18 RPL14 human exp
P05783 P05783 P27361 KRT18 MAPK3 human ortho,pred
P05783 P05783 O14964 KRT18 HGS human exp
P05783 P05783 Q9NRI5 KRT18 DISC1 human pred
P05783 P05783 P50570 KRT18 DNM2 human pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.