Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 12 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
P14207 P14207 P11487 FOLR2 FGF3 human pred
P14207 P14207 P08571 FOLR2 CD14 human pred
P14207 P14207 P41440 FOLR2 SLC19A1 human pred
P14207 P14207 O94956 FOLR2 SLCO2B1 human pred
P14207 P14207 Q01850 FOLR2 CDR2 human exp
P14207 P14207 P02745 FOLR2 C1QA human pred
P14207 P14207 P41439 FOLR2 FOLR3 human pred
P14207 P14207 P55008 FOLR2 AIF1 human pred
P14207 P14207 P15328 FOLR2 FOLR1 human pred
P14207 P14207 Q9Y279 FOLR2 VSIG4 human pred
P14207 P14207 Q9H2D1 FOLR2 SLC25A32 human pred
P14207 P14207 Q9NY15 FOLR2 STAB1 human pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.