Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 21 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
P42127 P42127 P31645 ASIP SLC6A4 human pred
P42127 P42127 Q9NSD5 ASIP SLC6A13 human pred
P42127 P42127 P54219 ASIP SLC18A1 human pred
P42127 P42127 O75056 ASIP SDC3 human pred
P42127 P42127 Q13509 ASIP TUBB3 human pred
P42127 P42127 Q01726 ASIP MC1R human exp
P42127 P42127 P33032 ASIP MC5R human exp
P42127 P42127 P32245 ASIP MC4R human exp
P42127 P42127 O00341 ASIP SLC1A7 human pred
P42127 P42127 P48066 ASIP SLC6A11 human pred
P42127 P42127 P41968 ASIP MC3R human exp
P42127 P42127 P48065 ASIP SLC6A12 human pred
P42127 P42127 Q9ULA0 ASIP DNPEP human pred
P42127 P42127 Q01959 ASIP SLC6A3 human pred
P42127 P42127 Q8TCU3 ASIP SLC7A13 human pred
P42127 P42127 Q401N2 ASIP ZACN human pred
P42127 P42127 P32247 ASIP BRS3 human pred
P42127 P42127 P23975 ASIP SLC6A2 human pred
P42127 P42127 Q9H252 ASIP KCNH6 human pred
P42127 P42127 Q01718 ASIP MC2R human exp
P42127 P42127 P48664 ASIP SLC1A6 human pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.