Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 27 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
P42330 P42330 P20813 AKR1C3 CYP2B6 human pred
P42330 P42330 P15121 AKR1C3 AKR1B1 human pred
P42330 P42330 Q5UIP0 AKR1C3 RIF1 human exp
P42330 P42330 P62258 AKR1C3 YWHAE human ortho
P42330 P42330 P17516 AKR1C3 AKR1C4 human exp,pred
P42330 P42330 Q9UKY1 AKR1C3 ZHX1 human exp
P42330 P42330 P09917 AKR1C3 ALOX5 human pred
P42330 P42330 Q9UKV3 AKR1C3 ACIN1 human exp
P42330 P42330 Q96SQ9 AKR1C3 CYP2S1 human pred
P42330 P42330 O60218 AKR1C3 AKR1B10 human pred
P42330 P42330 Q9UPM9 AKR1C3 B9D1 human ortho
P42330 P42330 P63104 AKR1C3 YWHAZ human ortho
P42330 P42330 Q96JD6 AKR1C3 AKR1E2 human pred
P42330 P42330 Q16698 AKR1C3 DECR1 human pred
P42330 P42330 O43255 AKR1C3 SIAH2 human exp
P42330 P42330 P43364 AKR1C3 MAGEA11 human exp
P42330 P42330 P55316 AKR1C3 FOXG1 human pred
P42330 P42330 P05181 AKR1C3 CYP2E1 human pred
P42330 P42330 P04798 AKR1C3 CYP1A1 human pred
P42330 P42330 P51857 AKR1C3 AKR1D1 human exp,pred
P42330 P42330 Q04828 AKR1C3 AKR1C1 human exp,pred
P42330 P42330 Q96B02 AKR1C3 UBE2W human exp
P42330 P42330 P42330 AKR1C3 AKR1C3 human pred
P42330 P42330 P52895 AKR1C3 AKR1C2 human exp,pred
P42330 P42330 P14550 AKR1C3 AKR1A1 human pred
P42330 P42330 Q5T3J3 AKR1C3 LRIF1 human exp
P42330 P42330 P24903 AKR1C3 CYP2F1 human pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.