Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 25 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
P43251 P43251 Q15262 BTD PTPRK human exp
P43251 P43251 P34896 BTD SHMT1 human pred
P43251 P43251 Q9BRV8 BTD SIKE1 human exp
P43251 P43251 P24385 BTD CCND1 human exp
P43251 P43251 P09622 BTD DLD human pred
P43251 P43251 P05089 BTD ARG1 human pred
P43251 P43251 Q96T91 BTD GPHA2 human exp
P43251 P43251 Q16635 BTD TAZ human exp
P43251 P43251 Q13203 BTD MYBPH human pred
P43251 P43251 P0CG48 BTD UBC human exp
P43251 P43251 P01008 BTD SERPINC1 human exp
P43251 P43251 Q9BS26 BTD ERP44 human exp
P43251 P43251 Q9NRD1 BTD FBXO6 human exp
P43251 P43251 Q86YD3 BTD TMEM25 human exp
P43251 P43251 P00966 BTD ASS1 human pred
P43251 P43251 O75037 BTD KIF21B human exp
P43251 P43251 Q96FF9 BTD CDCA5 human exp
P43251 P43251 O15178 BTD T human pred
P43251 P43251 P50747 BTD HLCS human pred
P43251 P43251 P48506 BTD GCLC human pred
P43251 P43251 P23378 BTD GLDC human pred
P43251 P43251 O94832 BTD MYO1D human exp
P43251 P43251 Q96RQ3 BTD MCCC1 human pred
P43251 P43251 Q9Y234 BTD LIPT1 human pred
P43251 P43251 P11498 BTD PC human pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.