Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 21 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
P48378 P48378 Q13227 RFX2 GPS2 human ortho
P48378 P48378 Q92823 RFX2 NRCAM human pred
P48378 P48378 Q9NPC7 RFX2 MYNN human ortho
P48378 P48378 P22670 RFX2 RFX1 human exp,pred
P48378 P48378 P22492 RFX2 HIST1H1T human pred
P48378 P48378 Q99750 RFX2 MDFI human exp
P48378 P48378 O00409 RFX2 FOXN3 human exp
P48378 P48378 Q9P0K8 RFX2 FOXJ2 human exp
P48378 P48378 Q33E94 RFX2 RFX4 human exp,pred
P48378 P48378 P51532 RFX2 SMARCA4 human pred
P48378 P48378 P48378 RFX2 RFX2 human exp
P48378 P48378 Q9BVI0 RFX2 PHF20 human pred
P48378 P48378 P41227 RFX2 NAA10 human pred
P48378 P48378 P48380 RFX2 RFX3 human pred
P48378 P48378 Q8HWS3 RFX2 RFX6 human exp
P48378 P48378 Q9UKT7 RFX2 FBXL3 human exp
P48378 P48378 P51531 RFX2 SMARCA2 human pred
P48378 P48378 Q92949 RFX2 FOXJ1 human exp,ortho
P48378 P48378 Q6P1W5 RFX2 C1orf94 human exp
P48378 P48378 P52926 RFX2 HMGA2 human ortho
P48378 P48378 P32314 RFX2 FOXN2 human exp

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.