Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 29 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
P52895 P52895 P29401 AKR1C2 TKT human exp
P52895 P52895 P14174 AKR1C2 MIF human exp
P52895 P52895 P42330 AKR1C2 AKR1C3 human exp,pred
P52895 P52895 P22102 AKR1C2 GART human exp
P52895 P52895 O60218 AKR1C2 AKR1B10 human pred
P52895 P52895 P10109 AKR1C2 FDX1 human pred
P52895 P52895 P00441 AKR1C2 SOD1 human exp
P52895 P52895 O15397 AKR1C2 IPO8 human exp
P52895 P52895 P15121 AKR1C2 AKR1B1 human pred
P52895 P52895 Q96JD6 AKR1C2 AKR1E2 human pred
P52895 P52895 Q96SQ9 AKR1C2 CYP2S1 human pred
P52895 P52895 P17516 AKR1C2 AKR1C4 human exp,pred
P52895 P52895 P20813 AKR1C2 CYP2B6 human pred
P52895 P52895 O43520 AKR1C2 ATP8B1 human pred
P52895 P52895 P05181 AKR1C2 CYP2E1 human pred
P52895 P52895 P48507 AKR1C2 GCLM human pred
P52895 P52895 Q6P2D0 AKR1C2 ZFP1 human exp
P52895 P52895 P14550 AKR1C2 AKR1A1 human pred
P52895 P52895 P24903 AKR1C2 CYP2F1 human pred
P52895 P52895 P51857 AKR1C2 AKR1D1 human pred
P52895 P52895 Q16698 AKR1C2 DECR1 human pred
P52895 P52895 Q9H0W9 AKR1C2 C11orf54 human exp
P52895 P52895 O60493 AKR1C2 SNX3 human exp
P52895 P52895 Q9H1K1 AKR1C2 ISCU human pred
P52895 P52895 P22061 AKR1C2 PCMT1 human exp
P52895 P52895 P52895 AKR1C2 AKR1C2 human exp,pred
P52895 P52895 O43504 AKR1C2 LAMTOR5 human exp
P52895 P52895 Q04828 AKR1C2 AKR1C1 human exp,pred
P52895 P52895 P78385 AKR1C2 KRT83 human pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.