Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 27 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
P54098 P54098 Q9BQ50 POLG TREX2 human pred
P54098 P54098 P12235 POLG SLC25A4 human pred
P54098 P54098 Q12829 POLG RAB40B human ortho
P54098 P54098 Q13469 POLG NFATC2 human exp
P54098 P54098 P12004 POLG PCNA human pred
P54098 P54098 P36776 POLG LONP1 human pred
P54098 P54098 Q5BKU9 POLG OXLD1 human exp
P54098 P54098 P01106 POLG MYC human exp
P54098 P54098 P49916 POLG LIG3 human pred
P54098 P54098 Q8WVC6 POLG DCAKD human ortho
P54098 P54098 Q04837 POLG SSBP1 human exp,pred
P54098 P54098 Q9H7X7 POLG IFT22 human ortho
P54098 P54098 P54098 POLG POLG human exp
P54098 P54098 Q9Y294 POLG ASF1A human ortho
P54098 P54098 Q14CZ7 POLG FASTKD3 human exp
P54098 P54098 P13591 POLG NCAM1 human ortho
P54098 P54098 Q8IVS2 POLG MCAT human pred
P54098 P54098 Q9H967 POLG WDR76 human ortho
P54098 P54098 O00716 POLG E2F3 human exp
P54098 P54098 P04179 POLG SOD2 human ortho
P54098 P54098 P04637 POLG TP53 human ortho
P54098 P54098 Q9P2R7 POLG SUCLA2 human pred
P54098 P54098 Q712K3 POLG UBE2R2 human ortho
P54098 P54098 Q8TCD5 POLG NT5C human pred
P54098 P54098 Q9BYD3 POLG MRPL4 human exp
P54098 P54098 P26583 POLG HMGB2 human pred
P54098 P54098 Q9UHN1 POLG POLG2 human exp,pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.