Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 22 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
P69892 P69892 P00387 HBG2 CYB5R3 human exp
P69892 P69892 P02100 HBG2 HBE1 human pred
P69892 P69892 P02144 HBG2 MB human pred
P69892 P69892 P08865 HBG2 RPSA human exp
P69892 P69892 P68871 HBG2 HBB human exp,pred
P69892 P69892 Q8IUH5 HBG2 ZDHHC17 human exp
P69892 P69892 Q8WWM9 HBG2 CYGB human pred
P69892 P69892 P69891 HBG2 HBG1 human exp,pred
P69892 P69892 P69905 HBG2 HBA1 human exp,pred
P69892 P69892 Q6B0K9 HBG2 HBM human pred
P69892 P69892 P69892 HBG2 HBG2 human exp,pred
P69892 P69892 P09105 HBG2 HBQ1 human pred
P69892 P69892 Q99717 HBG2 SMAD5 human exp
P69892 P69892 P13612 HBG2 ITGA4 human exp
P69892 P69892 P05067 HBG2 APP human exp
P69892 P69892 P02008 HBG2 HBZ human exp,pred
P69892 P69892 P49736 HBG2 MCM2 human exp
P69892 P69892 P60411 HBG2 KRTAP10-9 human exp
P69892 P69892 Q9NPG2 HBG2 NGB human pred
P69892 P69892 P21860 HBG2 ERBB3 human exp
P69892 P69892 P02042 HBG2 HBD human pred
P69892 P69892 P19320 HBG2 VCAM1 human exp

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.