Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:


Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues




Results exceeding 3000 interactions will be returned as a downloadable file
  


Results

Retrieved 156 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
P78536 P78536 P42229 ADAM17 STAT5A human pred
P78536 P78536 P08887 ADAM17 IL6R human exp
P78536 P78536 P20333 ADAM17 TNFRSF1B human exp,pred
P78536 P78536 P22460 ADAM17 KCNA5 human pred
P78536 P78536 P46531 ADAM17 NOTCH1 human exp,pred
P78536 P78536 P21810 ADAM17 BGN human pred
P78536 P78536 P27986 ADAM17 PIK3R1 human pred
P78536 P78536 O15111 ADAM17 CHUK human pred
P78536 P78536 Q8IUQ4 ADAM17 SIAH1 human pred
P78536 P78536 Q9ULV5 ADAM17 HSF4 human pred
P78536 P78536 Q15013 ADAM17 MAD2L1BP human pred
P78536 P78536 P78325 ADAM17 ADAM8 human pred
P78536 P78536 P17252 ADAM17 PRKCA human pred
P78536 P78536 Q9UI95 ADAM17 MAD2L2 human exp,pred
P78536 P78536 P06239 ADAM17 LCK human pred
P78536 P78536 P08581 ADAM17 MET human pred
P78536 P78536 P49757 ADAM17 NUMB human pred
P78536 P78536 P05067 ADAM17 APP human exp
P78536 P78536 O75077 ADAM17 ADAM23 human pred
P78536 P78536 P62993 ADAM17 GRB2 human exp
P78536 P78536 Q9UQM7 ADAM17 CAMK2A human pred
P78536 P78536 Q04721 ADAM17 NOTCH2 human pred
P78536 P78536 P27361 ADAM17 MAPK3 human exp,pred
P78536 P78536 P19438 ADAM17 TNFRSF1A human exp
P78536 P78536 P25098 ADAM17 GRK2 human pred
P78536 P78536 Q15256 ADAM17 PTPRR human pred
P78536 P78536 Q93009 ADAM17 USP7 human pred
P78536 P78536 O14490 ADAM17 DLGAP1 human pred
P78536 P78536 Q92585 ADAM17 MAML1 human pred
P78536 P78536 P36956 ADAM17 SREBF1 human pred
P78536 P78536 P53355 ADAM17 DAPK1 human pred
P78536 P78536 Q16665 ADAM17 HIF1A human pred
P78536 P78536 O60504 ADAM17 SORBS3 human pred
P78536 P78536 P49407 ADAM17 ARRB1 human pred
P78536 P78536 Q12913 ADAM17 PTPRJ human pred
P78536 P78536 Q5JRA6 ADAM17 MIA3 human pred
P78536 P78536 Q07021 ADAM17 C1QBP human pred
P78536 P78536 P19634 ADAM17 SLC9A1 human pred
P78536 P78536 P35625 ADAM17 TIMP3 human exp,pred
P78536 P78536 Q8TE59 ADAM17 ADAMTS19 human pred
P78536 P78536 Q9Y219 ADAM17 JAG2 human pred
P78536 P78536 P56524 ADAM17 HDAC4 human pred
P78536 P78536 Q15628 ADAM17 TRADD human pred
P78536 P78536 Q9Y3Q7 ADAM17 ADAM18 human pred
P78536 P78536 Q8WXS8 ADAM17 ADAMTS14 human pred
P78536 P78536 Q13443 ADAM17 ADAM9 human pred
P78536 P78536 P12931 ADAM17 SRC human exp
P78536 P78536 P60983 ADAM17 GMFB human pred
P78536 P78536 P51452 ADAM17 DUSP3 human pred
P78536 P78536 Q15303 ADAM17 ERBB4 human exp
P78536 P78536 Q5JTD0 ADAM17 TJAP1 human pred
P78536 P78536 Q02410 ADAM17 APBA1 human pred
P78536 P78536 Q9HCE7 ADAM17 SMURF1 human pred
P78536 P78536 P01375 ADAM17 TNF human exp,pred
P78536 P78536 P36896 ADAM17 ACVR1B human pred
P78536 P78536 P55290 ADAM17 CDH13 human pred
P78536 P78536 P49023 ADAM17 PXN human exp
P78536 P78536 Q9NRD1 ADAM17 FBXO6 human exp
P78536 P78536 P30101 ADAM17 PDIA3 human exp
P78536 P78536 Q00613 ADAM17 HSF1 human pred
P78536 P78536 P01135 ADAM17 TGFA human exp,pred
P78536 P78536 Q9NRR6 ADAM17 INPP5E human pred
P78536 P78536 P55072 ADAM17 VCP human pred
P78536 P78536 Q86Y01 ADAM17 DTX1 human pred
P78536 P78536 Q15349 ADAM17 RPS6KA2 human pred
P78536 P78536 Q9HAU4 ADAM17 SMURF2 human pred
P78536 P78536 Q9UP79 ADAM17 ADAMTS8 human pred
P78536 P78536 Q6PJF5 ADAM17 RHBDF2 human ortho
P78536 P78536 Q13573 ADAM17 SNW1 human pred
P78536 P78536 P28482 ADAM17 MAPK1 human exp,pred
P78536 P78536 P26045 ADAM17 PTPN3 human exp
P78536 P78536 O75078 ADAM17 ADAM11 human pred
P78536 P78536 P04049 ADAM17 RAF1 human pred
P78536 P78536 P51812 ADAM17 RPS6KA3 human pred
P78536 P78536 Q9UGM3 ADAM17 DMBT1 human pred
P78536 P78536 Q02156 ADAM17 PRKCE human pred
P78536 P78536 P28324 ADAM17 ELK4 human pred
P78536 P78536 Q9HBH9 ADAM17 MKNK2 human pred
P78536 P78536 P23469 ADAM17 PTPRE human pred
P78536 P78536 Q15121 ADAM17 PEA15 human pred
P78536 P78536 P18564 ADAM17 ITGB6 human pred
P78536 P78536 P16035 ADAM17 TIMP2 human pred
P78536 P78536 Q14192 ADAM17 FHL2 human exp,pred
P78536 P78536 O00587 ADAM17 MFNG human pred
P78536 P78536 O75530 ADAM17 EED human exp
P78536 P78536 O00305 ADAM17 CACNB4 human pred
P78536 P78536 Q9UEF7 ADAM17 KL human pred
P78536 P78536 O15205 ADAM17 UBD human pred
P78536 P78536 Q99727 ADAM17 TIMP4 human pred
P78536 P78536 Q16820 ADAM17 MEP1B human pred
P78536 P78536 Q9Y6D9 ADAM17 MAD1L1 human pred
P78536 P78536 Q02750 ADAM17 MAP2K1 human pred
P78536 P78536 O43847 ADAM17 NRDC human pred
P78536 P78536 P23560 ADAM17 BDNF human pred
P78536 P78536 Q13444 ADAM17 ADAM15 human pred
P78536 P78536 Q13501 ADAM17 SQSTM1 human pred
P78536 P78536 P03372 ADAM17 ESR1 human pred
P78536 P78536 P16581 ADAM17 SELE human pred
P78536 P78536 Q9BUB5 ADAM17 MKNK1 human pred
P78536 P78536 P78423 ADAM17 CX3CL1 human pred
P78536 P78536 P01033 ADAM17 TIMP1 human pred
P78536 P78536 O15530 ADAM17 PDPK1 human exp
P78536 P78536 P05556 ADAM17 ITGB1 human exp,ortho
P78536 P78536 P35236 ADAM17 PTPN7 human pred
P78536 P78536 P78504 ADAM17 JAG1 human exp
P78536 P78536 O14910 ADAM17 LIN7A human pred
P78536 P78536 Q8NES3 ADAM17 LFNG human pred
P78536 P78536 Q14289 ADAM17 PTK2B human pred
P78536 P78536 P05771 ADAM17 PRKCB human pred
P78536 P78536 P98170 ADAM17 XIAP human pred
P78536 P78536 P01106 ADAM17 MYC human pred
P78536 P78536 Q16819 ADAM17 MEP1A human pred
P78536 P78536 Q99965 ADAM17 ADAM2 human pred
P78536 P78536 Q9BZ11 ADAM17 ADAM33 human pred
P78536 P78536 O14672 ADAM17 ADAM10 human pred
P78536 P78536 Q13257 ADAM17 MAD2L1 human exp,pred
P78536 P78536 Q96KB5 ADAM17 PBK human pred
P78536 P78536 Q16828 ADAM17 DUSP6 human pred
P78536 P78536 Q13635 ADAM17 PTCH1 human exp
P78536 P78536 O94813 ADAM17 SLIT2 human pred
P78536 P78536 Q13546 ADAM17 RIPK1 human pred
P78536 P78536 O43639 ADAM17 NCK2 human pred
P78536 P78536 Q6IA17 ADAM17 SIGIRR human pred
P78536 P78536 P07996 ADAM17 THBS1 human pred
P78536 P78536 P10415 ADAM17 BCL2 human pred
P78536 P78536 Q76LX8 ADAM17 ADAMTS13 human pred
P78536 P78536 Q9NRD9 ADAM17 DUOX1 human pred
P78536 P78536 P27930 ADAM17 IL1R2 human exp
P78536 P78536 O95631 ADAM17 NTN1 human pred
P78536 P78536 Q02763 ADAM17 TEK human pred
P78536 P78536 P08648 ADAM17 ITGA5 human pred
P78536 P78536 O14936 ADAM17 CASK human pred
P78536 P78536 Q12959 ADAM17 DLG1 human exp
P78536 P78536 O14788 ADAM17 TNFSF11 human exp,pred
P78536 P78536 P19419 ADAM17 ELK1 human pred
P78536 P78536 P49841 ADAM17 GSK3B human pred
P78536 P78536 P67809 ADAM17 YBX1 human pred
P78536 P78536 P43403 ADAM17 ZAP70 human pred
P78536 P78536 P28562 ADAM17 DUSP1 human pred
P78536 P78536 P17302 ADAM17 GJA1 human pred
P78536 P78536 Q96NY8 ADAM17 NECTIN4 human pred
P78536 P78536 Q15418 ADAM17 RPS6KA1 human pred
P78536 P78536 P40763 ADAM17 STAT3 human pred
P78536 P78536 P42261 ADAM17 GRIA1 human pred
P78536 P78536 Q12772 ADAM17 SREBF2 human pred
P78536 P78536 Q5HYK7 ADAM17 SH3D19 human exp
P78536 P78536 O43255 ADAM17 SIAH2 human pred
P78536 P78536 P49815 ADAM17 TSC2 human pred
P78536 P78536 P05787 ADAM17 KRT8 human pred
P78536 P78536 P46734 ADAM17 MAP2K3 human pred
P78536 P78536 O14944 ADAM17 EREG human pred
P78536 P78536 Q9NUP9 ADAM17 LIN7C human pred
P78536 P78536 P15336 ADAM17 ATF2 human pred
P78536 P78536 Q12933 ADAM17 TRAF2 human pred
P78536 P78536 P06213 ADAM17 INSR human pred
P78536 P78536 Q8TC27 ADAM17 ADAM32 human pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.