Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 25 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
Q04741 Q04741 P55075 EMX1 FGF8 human pred
Q04741 Q04741 O14770 EMX1 MEIS2 human ortho
Q04741 Q04741 O94953 EMX1 KDM4B human ortho
Q04741 Q04741 P20823 EMX1 HNF1A human ortho
Q04741 Q04741 P04628 EMX1 WNT1 human pred
Q04741 Q04741 P17947 EMX1 SPI1 human ortho
Q04741 Q04741 Q9NPC3 EMX1 CCNB1IP1 human ortho
Q04741 Q04741 Q00978 EMX1 IRF9 human ortho
Q04741 Q04741 P52655 EMX1 GTF2A1 human ortho
Q04741 Q04741 P32243 EMX1 OTX2 human ortho
Q04741 Q04741 Q9UNN4 EMX1 GTF2A1L human exp
Q04741 Q04741 O95238 EMX1 SPDEF human ortho
Q04741 Q04741 P19419 EMX1 ELK1 human exp
Q04741 Q04741 P11473 EMX1 VDR human ortho
Q04741 Q04741 O15514 EMX1 POLR2D human exp
Q04741 Q04741 Q9H161 EMX1 ALX4 human exp
Q04741 Q04741 P56706 EMX1 WNT7B human pred
Q04741 Q04741 P31314 EMX1 TLX1 human ortho
Q04741 Q04741 P31260 EMX1 HOXA10 human exp
Q04741 Q04741 Q9UKN5 EMX1 PRDM4 human exp
Q04741 Q04741 Q92985 EMX1 IRF7 human ortho
Q04741 Q04741 Q02535 EMX1 ID3 human ortho
Q04741 Q04741 Q92908 EMX1 GATA6 human ortho
Q04741 Q04741 Q93097 EMX1 WNT2B human pred
Q04741 Q04741 Q9H3D4 EMX1 TP63 human exp

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.