Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 11 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
Q2YD98 Q2YD98 Q96EB6 UVSSA SIRT1 human exp
Q2YD98 Q2YD98 P46379 UVSSA BAG6 human exp
Q2YD98 Q2YD98 P32780 UVSSA GTF2H1 human exp
Q2YD98 Q2YD98 P19447 UVSSA ERCC3 human exp
Q2YD98 Q2YD98 Q13216 UVSSA ERCC8 human exp
Q2YD98 Q2YD98 O60506 UVSSA SYNCRIP human exp
Q2YD98 Q2YD98 Q16531 UVSSA DDB1 human exp
Q2YD98 Q2YD98 P50613 UVSSA CDK7 human exp
Q2YD98 Q2YD98 O15047 UVSSA SETD1A human exp
Q2YD98 Q2YD98 Q93009 UVSSA USP7 human exp
Q2YD98 Q2YD98 P18074 UVSSA ERCC2 human exp

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.