Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 14 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
Q6NSJ2 Q6NSJ2 Q86WV1 PHLDB3 SKAP1 human exp
Q6NSJ2 Q6NSJ2 Q96QT4 PHLDB3 TRPM7 human ortho
Q6NSJ2 Q6NSJ2 P13727 PHLDB3 PRG2 human exp
Q6NSJ2 Q6NSJ2 Q5H9I0 PHLDB3 TFDP3 human exp
Q6NSJ2 Q6NSJ2 P57078 PHLDB3 RIPK4 human exp
Q6NSJ2 Q6NSJ2 Q96NL6 PHLDB3 SCLT1 human exp
Q6NSJ2 Q6NSJ2 Q96EB6 PHLDB3 SIRT1 human exp
Q6NSJ2 Q6NSJ2 Q9HC77 PHLDB3 CENPJ human exp
Q6NSJ2 Q6NSJ2 Q8N344 PHLDB3 MIER2 human exp
Q6NSJ2 Q6NSJ2 Q9NS73 PHLDB3 MBIP human exp
Q6NSJ2 Q6NSJ2 Q8IX90 PHLDB3 SKA3 human exp
Q6NSJ2 Q6NSJ2 Q8WWY8 PHLDB3 LIPH human exp
Q6NSJ2 Q6NSJ2 P24387 PHLDB3 CRHBP human exp
Q6NSJ2 Q6NSJ2 P43115 PHLDB3 PTGER3 human exp

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.