Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 9 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
Q6PIU2 Q6PIU2 Q9H6F2 NCEH1 TMEM38A human exp
Q6PIU2 Q6PIU2 P22794 NCEH1 EVI2A human exp
Q6PIU2 Q6PIU2 O95274 NCEH1 LYPD3 human exp
Q6PIU2 Q6PIU2 Q96EQ0 NCEH1 SGTB human exp
Q6PIU2 Q6PIU2 P63104 NCEH1 YWHAZ human ortho
Q6PIU2 Q6PIU2 P62258 NCEH1 YWHAE human ortho
Q6PIU2 Q6PIU2 O75208 NCEH1 COQ9 human exp
Q6PIU2 Q6PIU2 Q8ND25 NCEH1 ZNRF1 human exp
Q6PIU2 Q6PIU2 P53396 NCEH1 ACLY human pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.