Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 11 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
Q7Z418 Q7Z418 P37173 KCNK18 TGFBR2 human exp
Q7Z418 Q7Z418 P36897 KCNK18 TGFBR1 human exp
Q7Z418 Q7Z418 P22001 KCNK18 KCNA3 human pred
Q7Z418 Q7Z418 P17658 KCNK18 KCNA6 human pred
Q7Z418 Q7Z418 Q9HB14 KCNK18 KCNK13 human pred
Q7Z418 Q7Z418 Q8TDN1 KCNK18 KCNG4 human pred
Q7Z418 Q7Z418 Q9H2S1 KCNK18 KCNN2 human pred
Q7Z418 Q7Z418 Q9NYG8 KCNK18 KCNK4 human pred
Q7Z418 Q7Z418 O15554 KCNK18 KCNN4 human pred
Q7Z418 Q7Z418 P57789 KCNK18 KCNK10 human pred
Q7Z418 Q7Z418 Q12791 KCNK18 KCNMA1 human pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.