Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 12 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
Q8IYL3 Q8IYL3 Q8N165 C1orf174 PDIK1L human exp
Q8IYL3 Q8IYL3 Q9NYB0 C1orf174 TERF2IP human exp
Q8IYL3 Q8IYL3 Q7L5N1 C1orf174 COPS6 human exp
Q8IYL3 Q8IYL3 O14980 C1orf174 XPO1 human exp
Q8IYL3 Q8IYL3 Q8NBJ4 C1orf174 GOLM1 human exp
Q8IYL3 Q8IYL3 Q13422 C1orf174 IKZF1 human exp
Q8IYL3 Q8IYL3 P26641 C1orf174 EEF1G human exp
Q8IYL3 Q8IYL3 Q92993 C1orf174 KAT5 human exp
Q8IYL3 Q8IYL3 P05067 C1orf174 APP human exp
Q8IYL3 Q8IYL3 Q8TDR2 C1orf174 STK35 human exp
Q8IYL3 Q8IYL3 P78362 C1orf174 SRPK2 human exp
Q8IYL3 Q8IYL3 Q15717 C1orf174 ELAVL1 human exp

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.