Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 9 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
Q8NAP8 Q8NAP8 Q16630 ZBTB8B CPSF6 human exp
Q8NAP8 Q8NAP8 O43314 ZBTB8B PPIP5K2 human exp
Q8NAP8 Q8NAP8 Q6PFW1 ZBTB8B PPIP5K1 human exp
Q8NAP8 Q8NAP8 Q12905 ZBTB8B ILF2 human exp
Q8NAP8 Q8NAP8 Q8NBE8 ZBTB8B KLHL23 human pred
Q8NAP8 Q8NAP8 Q9HCE7 ZBTB8B SMURF1 human exp
Q8NAP8 Q8NAP8 P33176 ZBTB8B KIF5B human exp
Q8NAP8 Q8NAP8 Q8NDD8 ZBTB8B DKFZp564H223 human exp
Q8NAP8 Q8NAP8 Q9UK45 ZBTB8B LSM7 human exp

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.