Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 9 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
Q8NC06 Q8NC06 Q8N6N7 ACBD4 ACBD7 human pred
Q8NC06 Q8NC06 O75521 ACBD4 ECI2 human pred
Q8NC06 Q8NC06 P05067 ACBD4 APP human exp
Q8NC06 Q8NC06 Q5T8D3 ACBD4 ACBD5 human pred
Q8NC06 Q8NC06 Q9BR61 ACBD4 ACBD6 human pred
Q8NC06 Q8NC06 Q9P0L0 ACBD4 VAPA human exp
Q8NC06 Q8NC06 Q8NC06 ACBD4 ACBD4 human pred
Q8NC06 Q8NC06 P07108 ACBD4 DBI human pred
Q8NC06 Q8NC06 O95292 ACBD4 VAPB human exp

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.