Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 8 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
Q8NHX4 Q8NHX4 P60410 SPATA3 KRTAP10-8 human exp
Q8NHX4 Q8NHX4 P60411 SPATA3 KRTAP10-9 human exp
Q8NHX4 Q8NHX4 Q9NPC3 SPATA3 CCNB1IP1 human ortho
Q8NHX4 Q8NHX4 Q9BYR5 SPATA3 KRTAP4-2 human exp
Q8NHX4 Q8NHX4 P60369 SPATA3 KRTAP10-3 human exp
Q8NHX4 Q8NHX4 Q99750 SPATA3 MDFI human exp
Q8NHX4 Q8NHX4 Q9BQ66 SPATA3 KRTAP4-12 human exp
Q8NHX4 Q8NHX4 P60409 SPATA3 KRTAP10-7 human exp

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.