Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 15 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
Q8WVP7 Q8WVP7 Q92633 LMBR1 LPAR1 human exp
Q8WVP7 Q8WVP7 P25101 LMBR1 EDNRA human exp
Q8WVP7 Q8WVP7 P43657 LMBR1 LPAR6 human exp
Q8WVP7 Q8WVP7 Q15465 LMBR1 SHH human pred
Q8WVP7 Q8WVP7 P43115 LMBR1 PTGER3 human exp
Q8WVP7 Q8WVP7 P07307 LMBR1 ASGR2 human exp
Q8WVP7 Q8WVP7 Q4W5P6 LMBR1 TMEM155 human exp
Q8WVP7 Q8WVP7 Q86Y78 LMBR1 LYPD6 human exp
Q8WVP7 Q8WVP7 Q9H244 LMBR1 P2RY12 human exp
Q8WVP7 Q8WVP7 P52799 LMBR1 EFNB2 human exp
Q8WVP7 Q8WVP7 Q9Y2T5 LMBR1 GPR52 human exp
Q8WVP7 Q8WVP7 Q401N2 LMBR1 ZACN human exp
Q8WVP7 Q8WVP7 O95274 LMBR1 LYPD3 human exp
Q8WVP7 Q8WVP7 Q9NQS5 LMBR1 GPR84 human exp
Q8WVP7 Q8WVP7 Q05996 LMBR1 ZP2 human pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.