Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 6 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
Q96KN8 Q96KN8 P05067 HRASLS5 APP human exp
Q96KN8 Q96KN8 Q9BVM4 HRASLS5 GGACT human exp
Q96KN8 Q96KN8 Q6ZMS7 HRASLS5 ZNF783 human exp
Q96KN8 Q96KN8 Q08379 HRASLS5 GOLGA2 human exp
Q96KN8 Q96KN8 Q96JH7 HRASLS5 VCPIP1 human exp
Q96KN8 Q96KN8 P49759 HRASLS5 CLK1 human exp

Return to Output Options

Return to top

Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.