Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 8 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
Q96P50 Q96P50 P16333 ACAP3 NCK1 human pred
Q96P50 Q96P50 P62993 ACAP3 GRB2 human pred
Q96P50 Q96P50 Q15750 ACAP3 TAB1 human exp
Q96P50 Q96P50 O14980 ACAP3 XPO1 human exp
Q96P50 Q96P50 P56537 ACAP3 EIF6 human exp
Q96P50 Q96P50 Q13352 ACAP3 ITGB3BP human exp
Q96P50 Q96P50 Q8TBE7 ACAP3 SLC35G2 human exp
Q96P50 Q96P50 P49023 ACAP3 PXN human pred

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.