Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 20 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
Q9NP58 Q9NP58 O95631 ABCB6 NTN1 human ortho
Q9NP58 Q9NP58 Q9Y282 ABCB6 ERGIC3 human exp
Q9NP58 Q9NP58 Q9NP58 ABCB6 ABCB6 human pred
Q9NP58 Q9NP58 O15439 ABCB6 ABCC4 human pred
Q9NP58 Q9NP58 Q14254 ABCB6 FLOT2 human exp
Q9NP58 Q9NP58 O96008 ABCB6 TOMM40 human exp
Q9NP58 Q9NP58 Q9H0E2 ABCB6 TOLLIP human exp
Q9NP58 Q9NP58 Q99496 ABCB6 RNF2 human exp
Q9NP58 Q9NP58 Q9BV68 ABCB6 RNF126 human exp
Q9NP58 Q9NP58 P04899 ABCB6 GNAI2 human exp
Q9NP58 Q9NP58 Q92569 ABCB6 PIK3R3 human exp
Q9NP58 Q9NP58 O75027 ABCB6 ABCB7 human pred
Q9NP58 Q9NP58 P35226 ABCB6 BMI1 human exp
Q9NP58 Q9NP58 P20036 ABCB6 HLA-DPA1 human exp
Q9NP58 Q9NP58 O15438 ABCB6 ABCC3 human pred
Q9NP58 Q9NP58 O15440 ABCB6 ABCC5 human pred
Q9NP58 Q9NP58 Q3KPI0 ABCB6 CEACAM21 human exp
Q9NP58 Q9NP58 O00560 ABCB6 SDCBP human exp
Q9NP58 Q9NP58 Q99816 ABCB6 TSG101 human exp
Q9NP58 Q9NP58 P01375 ABCB6 TNF human exp

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.