Find interaction partners supported by:

Experimental evidence
Orthologous interaction evidence
Computational predictions

Retrieve only interactions among query proteins
Include interactions among partners of query proteins

1. Enter protein, gene, or dataset IDs:

Maximum number of IDs: 100
Accepted IDs: Symbol (e.g., TP53), UniProt (e.g., P04637), Entrez Gene (e.g., 7157)

Options for searching across species:

Search using orthologs of your proteins
Return only interactions conserved across all selected species

2. Select species:

Options for searching across tissues:

Return only interactions present in all selected tissues
Required evidence: gene OR protein expression
Required evidence: gene AND protein expression

3. Select tissues:

Some tissues are not available for some species

Output Options

Information to include in output table:

Source information: detection methods, PubMed IDs, reporting databases
Tissue information: presence/absence of interactions in selected tissues

Results exceeding 3000 interactions will be returned as a downloadable file


Retrieved 19 PPIs for 1 ID

Query ID Query UniProt Partner UniProt Query Symbol Partner Symbol Species Evidence Type
Q9NVH6 Q9NVH6 Q13501 TMLHE SQSTM1 human exp
Q9NVH6 Q9NVH6 P14672 TMLHE SLC2A4 human ortho,pred
Q9NVH6 Q9NVH6 O75899 TMLHE GABBR2 human ortho
Q9NVH6 Q9NVH6 P06493 TMLHE CDK1 human ortho
Q9NVH6 Q9NVH6 Q9NVH6 TMLHE TMLHE human exp,ortho,pred
Q9NVH6 Q9NVH6 O75616 TMLHE ERAL1 human ortho
Q9NVH6 Q9NVH6 Q5VUM1 TMLHE C6orf57 human exp
Q9NVH6 Q9NVH6 O75936 TMLHE BBOX1 human pred
Q9NVH6 Q9NVH6 Q96FX7 TMLHE TRMT61A human ortho
Q9NVH6 Q9NVH6 Q9NWA0 TMLHE MED9 human exp
Q9NVH6 Q9NVH6 P52907 TMLHE CAPZA1 human ortho
Q9NVH6 Q9NVH6 Q16740 TMLHE CLPP human exp
Q9NVH6 Q9NVH6 Q9BTT4 TMLHE MED10 human exp
Q9NVH6 Q9NVH6 Q9HD26 TMLHE GOPC human ortho
Q9NVH6 Q9NVH6 P62258 TMLHE YWHAE human ortho
Q9NVH6 Q9NVH6 P05412 TMLHE JUN human exp
Q9NVH6 Q9NVH6 Q14197 TMLHE MRPL58 human exp
Q9NVH6 Q9NVH6 Q9NX70 TMLHE MED29 human exp
Q9NVH6 Q9NVH6 Q08999 TMLHE RBL2 human exp

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Citing IID

Kotlyar, M., Pastrello, C., Sheahan, N., Jurisica, I. Integrated Interactions Database: Tissue-specific view of the human and model organism interactomes, Nucleic Acids Res, 44(D1): D536-41, 2016.